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Differential expression of human granzymes A, B, and K in natural killer cells and during CD8<sup>+</sup> T cell differentiation in peripheral blood

16 Aug 2005

Abstract excerpt

NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) has been well characterized much less is known about the expression pattern of human granzyme K...

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PMID: 16106370
DOI: 10.1002/eji.200526122

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