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Activation of Human CD8+ T Cells Results in a Highly Selective and Very Potent Upregulation of Interferon-r, TNF-a, IL-2 and Granzyme B, But Not of Other Granzymes and Perforin

2025-10-24

Abstract excerpt

Cytotoxic T cells are fully immunocompetent only after full activation. In order to study this activation process and to identify the major changes in gene expression upon activation, human peripheral blood CD8+ T cells were purified and activated in vitro by anti-CD2, CD3 and CD28 coupled beads alone or in combination with recombinant IL-12 and IL-18. The changes in the transcriptomes were then analyzed by quanti...

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Literature Corpus work: 4786b7fe-8398-548e-97da-d3c18e2d1820
DOI: 10.20944/preprints202510.1922.v1

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