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Article

Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes.

Blood - 15 Dec 2007

Mateo Véronique, Ménager Michael, de Saint-Basile Geneviève, Stolzenberg Marie-Claude, Roquelaure Bertrand, André Nicolas, Florkin Benoit, le Deist Françoise, Picard Capucine, Fischer Alain, Rieux-Laucat Frédéric

Abstract excerpt

Activation-induced cell death (AICD) is involved in peripheral tolerance by controlling the expansion of repeatedly stimulated T cells via an apoptotic Fas (CD95; APO-1)-dependent pathway. The TNFRSF-6 gene encoding Fas is mutated in children suffering from autoimmune lymphoproliferative syndrome (ALPS), which is characterized by lymphoproliferation and autoimmunity. We examined AICD in Fas-deficient T cells from...

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Identifiers

PMID: 17724145
DOI: 10.1182/blood-2007-05-088286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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