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Identification of Human GATA-2 Gene Distal IS Exon and Its Expression in Hematopoietic Stem Cell Fractions

1 Jan 2000

Abstract excerpt

Transcription factor GATA-2 is essential for the proper function of hematopoietic stem cells and progenitors. Two first exons/promoters have been found in the mouse GATA-2 gene, and a distal IS promoter shows activity specific to hematopoietic progenitors and neural tissues. To ascertain whether the two-promoter system is also utilized in the human GATA-2 gene, we isolated and analyzed a P1 phage clone containing...

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PMID: 10731672
DOI: 10.1093/oxfordjournals.jbchem.a022570

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