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Article

A Block to Human Immunodeficiency Virus Type 1 Assembly in Murine Cells

15 Apr 2000

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) does not replicate in murine cells. We investigated the basis of this block by infecting a murine NIH 3T3 reporter cell line that stably expressed human CD4, CCR5, and cyclin T1 and contained a transactivatable HIV-1 long terminal repeat (LTR)-green fluorescent protein (GFP) cassette. Although the virus entered efficiently, formed provirus, and was expressed at a level...

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PMID: 10729160
DOI: 10.1128/jvi.74.8.3859-3870.2000

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