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Article

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.

Journal of virology - 1 Jul 1996

Pandori M W, Fitch N J, Craig H M, Richman D D, Spina C A, Guatelli J C

Abstract excerpt

Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is intact. This defect in infectivity causes nef-negative viruses to grow at an attenuated rate in vitro. To investigate the mechanism of Nef-mediated enhancement of viral growth rate and infectivity, a complementation analysis of nef mutant viruses was...

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Identifiers

PMID: 8676450
DOI: 10.1128/JVI.70.7.4283-4290.1996
PMCID: PMC190360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.PMID 8676450Read ↗

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.Semantic proximity Read ↗

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Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 NefSemantic proximity Read ↗

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity.Semantic proximity Read ↗

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entrySemantic proximity Read ↗

Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.Semantic proximity Read ↗

Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity.Semantic proximity Read ↗

Functional characterization of HIV-1 Nef mutants in the context of viral infection.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of VirionsSemantic proximity Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

Characterization of the Nef protein in HIV1-infected CEM cells.Semantic proximity Read ↗

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