Article
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
Journal of virology - 1 Jul 1996
Pandori M W, Fitch N J, Craig H M, Richman D D, Spina C A, Guatelli J C
Abstract excerpt
Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is intact. This defect in infectivity causes nef-negative viruses to grow at an attenuated rate in vitro. To investigate the mechanism of Ne...
Topics
- CD4-Positive T-Lymphocytes
- Cell Line
- Gene Products, nef
- Genetic Complementation Test
- HIV Core Protein p24
- HIV Protease
- HIV-1
- Mutation
- Myristic Acid
- Myristic Acids
- Recombinant Proteins
- Tumor Cells, Cultured
- Virion
- nef Gene Products, Human Immunodeficiency Virus