Article
Characterization of an envelope mutant of HIV-1 that interferes with viral infectivity.
Virology - 15 Dec 1996
Chen S S, Ferrante A A, Terwilliger E F
Abstract excerpt
A mutant human immunodeficiency virus (HIV-1) provirus encoding an envelope (Env) protein with a truncated transmembrane protein cytoplasmic domain was defective for replication. Coexpression of the mutant with a wild-type (wt) HIV-1 provirus potently inhibited the production of infectious virus....
Topics
- Animals
- CD4-Positive T-Lymphocytes
- COS Cells
- Cell Line
- DNA, Viral
- Gene Products, env
- Giant Cells
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Mutation
- Proviruses
- Transfection
- Viral Interference
- Virulence
- Virus Replication