Article
Murine T cells potently restrict human immunodeficiency virus infection.
Journal of virology - 1 Nov 2004
Baumann Jörg G, Unutmaz Derya, Miller Michael D, Breun Sabine K J, Grill Stacy M, Mirro Jane, Littman Dan R, Rein Alan, KewalRamani Vineet N
Abstract excerpt
Development of a mouse model for human immunodeficiency virus type 1 (HIV-1) infection has advanced through the progressive identification of host cell factors required for HIV-1 replication. Murine cells lack HIV-1 receptor molecules, do not support efficient viral gene expression, and lack factors necessary for the assembly and release of virions. Many of these blocks have been described using mouse fibroblast...
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