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Article

Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity.

Journal of virology - 1 Apr 1995

Borman A M, Quillent C, Charneau P, Dauguet C, Clavel F

Abstract excerpt

Disruption of the vif gene of human immunodeficiency virus (HIV) type 1 affects virus infectivity to various degrees, depending on the T-cell line used. We have concentrated our studies on true phenotypic Vif- mutant particles produced from CEMx174 or H9 cells. In a single round of infection, Vif- virus is approximately 25 (from CEMx174 cells) to 100 (from H9 cells) times less infectious than wild-type virus...

Topics

Base Sequence
Cells, Cultured
DNA, Viral
Gene Products, vif
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Phenotype
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virion

Virulence

Virus Replication

vif Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 7884851
DOI: 10.1128/JVI.69.4.2058-2067.1995
PMCID: PMC188871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7884851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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