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Article

Conditional multipoint linkage analysis using affected sib pairs: an alternative approach.

Genetic epidemiology - 1 Feb 2004

Chiu Yen-Feng, Liang Kung-Yee

Abstract excerpt

Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-decent) from affected sib pairs. This is carried out by conditioning on the IBD sharing value at the estimated trait locus of the reference region. Since markers...

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PMID: 14748010
DOI: 10.1002/gepi.10305

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