Conditional multipoint linkage analysis using affected sib pairs: an alternative approach.

doi:10.1002/gepi.10305

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Article

Conditional multipoint linkage analysis using affected sib pairs: an alternative approach.

Genetic epidemiology - 1 Feb 2004

Chiu Yen-Feng, Liang Kung-Yee

Abstract excerpt

Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identity-by-decent) from affected sib pairs. This is carried out by conditioning on the IBD sharing value at the estimated trait locus of the reference region. Since markers...

Topics

Alleles
Analysis of Variance
Chromosome Mapping
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 8
Genetic Heterogeneity
Genetic Markers
Genetic Predisposition to Disease
Humans
Models, Genetic
Models, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Pedigree

Phenotype

Probability

Quantitative Trait Loci

Schizophrenia

Siblings

Source

Open in PubMed

Identifiers

PMID: 14748010
DOI: 10.1002/gepi.10305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14748010-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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