Article
Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture.
The Journal of clinical investigation - 1 Mar 2000
Okada Y, Lorenzo J A, Freeman A M, Tomita M, Morham S G, Raisz L G, Pilbeam C C
Abstract excerpt
We examined the effect on osteoclast formation of disrupting the prostaglandin G/H synthase genes PGHS-1 and-2. Prostaglandin E(2) (PGE(2)) production was significantly reduced in marrow cultures from mice lacking PGHS-2 (PGHS-2(-/-)) compared with wild-type (PGHS-2(+/+)) cultures. Osteoclast formation, whether stimulated by 1,25-dihydroxyvitamin D(3) (1,25-D) or by parathyroid hormone (PTH), was reduced by...
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