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Article

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.

The Journal of biological chemistry - 30 Jun 2000

Miyaura C, Inada M, Suzawa T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T

Abstract excerpt

Prostaglandin E(2) (PGE(2)) acts as a potent stimulator of bone resorption. In this study, we first clarified in normal ddy mice the involvement of protein kinase A and induction of matrix metalloproteinases (MMPs) in PGE(2)-induced bone resorption, and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor. In calvarial...

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PMID: 10749873
DOI: 10.1074/jbc.M002079200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.PMID 10749873Read ↗

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