Article
Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.
The Journal of biological chemistry - 30 Jun 2000
Miyaura C, Inada M, Suzawa T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T
Abstract excerpt
Prostaglandin E(2) (PGE(2)) acts as a potent stimulator of bone resorption. In this study, we first clarified in normal ddy mice the involvement of protein kinase A and induction of matrix metalloproteinases (MMPs) in PGE(2)-induced bone resorption, and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor. In calvarial...
Topics
- Animals
- Animals, Newborn
- Blotting, Northern
- Blotting, Western
- Bone Resorption
- Bucladesine
- Cells, Cultured
- Collagenases
- Dinoprostone
- Dose-Response Relationship, Drug
- Gelatinases