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Article

Increased bone mass in adult prostacyclin-deficient mice.

The Journal of endocrinology - 1 Feb 2010

Nakalekha Chalida, Yokoyama Chieko, Miura Hiroyuki, Alles Neil, Aoki Kazuhiro, Ohya Keiichi, Morita Ikuo

Abstract excerpt

Prostaglandins (PGs) are key regulatory factors that affect bone metabolism. Prostaglandin E(2) (PGE(2)) regulates bone resorption and bone formation. Prostacyclin (PGI(2)) is one of the major products derived from arachidonic acid by the action of cyclooxygenase and PGI(2) synthase (PGIS). Unlike PGE(2), there are few reports about the role of PGI(2) in bone regulation. Therefore, we investigated the potential...

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Source

Identifiers

PMID: 19906840
DOI: 10.1677/JOE-09-0376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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