Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.

PloS one - 1 Jan 2013

Chabbi-Achengli Yasmine, Launay Jean-Marie, Maroteaux Luc, de Vernejoul Marie Christine, Collet Corinne

Abstract excerpt

Osteoporosis is due to an imbalance between decreased bone formation by osteoblasts and increased resorption by osteoclasts. Deciphering factors controlling bone formation is therefore of utmost importance for the understanding and the treatment of osteoporosis. Our previous in vivo results showed that bone formation is reduced in the absence of the serotonin receptor 5-HT2B, causing impaired osteoblast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cell Adhesion
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteoblasts

Share to PPAR delta

Share to Primary Cell Culture

Share to Sulfones

Share to Thiophenes

Source

Open in PubMed Open full text

Identifiers

PMID: 24069449
DOI: 10.1371/journal.pone.0075783
PMCID: PMC3775737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.PMID 24069449Read ↗

Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptorSemantic proximity Read ↗

5-HT <sub>2B</sub> serotonin receptor agonist BW723C86 shapes the macrophage gene profile via AhR and impairs monocyte-to-osteoclast differentiationSemantic proximity Read ↗

PPARβ/δ governs Wnt signaling and bone turnover.Semantic proximity Read ↗

Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells.Semantic proximity Read ↗

Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from ADRB2 Gene Polymorphism.Semantic proximity Read ↗

Osteoblast-targeted overexpression of PPARγ inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice.Semantic proximity Read ↗

Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.Semantic proximity Read ↗

Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo <i>via</i> an adenosine‐dependent mechanismSemantic proximity Read ↗

Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrualSemantic proximity Read ↗

Increased bone mass in adult prostacyclin-deficient mice.Semantic proximity Read ↗

Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.Semantic proximity Read ↗

Role of cAMP in phenotypic changes of osteoblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.