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Article

Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter.

Molecular and cellular endocrinology - 5 Feb 2010

Grzech Marjeta, Dahlhoff Maik, Herbach Nadja, Habermann Felix A, Renner-Müller Ingrid, Wanke Rüdiger, Flaswinkel Heinrich, Wolf Eckhard, Schneider Marlon R

Abstract excerpt

The availability of regulatory sequences directing tissue-specific expression of transgenes in genetically modified mice and large animals is a prerequisite for the development of adequate models for human diseases. The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic beta-cells of mice, also directs expression to extrapancreatic tissues and performs poorly in isolated...

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Identifiers

PMID: 19682540
DOI: 10.1016/j.mce.2009.08.001

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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