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Article

Evaluation of heterodimeric guanylyl cyclase genes as candidates for human hypertension.

Journal of hypertension - 1 Mar 2000

Danziger R S, Pappas C, Barnitz C, Varvil T, Hunt S C, Leppert M F

Abstract excerpt

OBJECTIVE: Both physiologic and pharmacological data have implicated the nitric oxide (NO) signaling cascade in the regulation of blood pressure in humans and its impairment in the pathogenesis of hypertension. In biological systems, the principal receptor for NO is NO-stimulated guanylyl cyclase. NO-stimulated guanylyl cyclases are obligate heterodimers (alpha/beta). The genes for guanylyl cyclase subunits...

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PMID: 10726711
DOI: 10.1097/00004872-200018030-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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