Article
G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 1998
Hegele R A, Harris S B, Hanley A J, Cao H, Zinman B
Abstract excerpt
The subunits of the heterotrimeric G proteins are attractive candidate gene products for both susceptibility to essential hypertension and interindividual variation in blood pressure. There is alternative splicing of exon 9 of the gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) associated with a C-->T change at nucleotide 825, which activates a cryptic splice site. The 825T allele results in a...
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