Article

C-terminal CDC42 variants in autoinflammatory patients specifically trigger actin defects and NF-κB hyperactivation

2024-06-30

Abstract excerpt

<h4>Background</h4> CDC42 belongs to the RHO GTPases family. Recently, four variants were identified in autoinflammatory patients. One variant affects the N-terminal part of the protein while the three others are located in the C-terminal region. To date, most of the functional defects were only reported for the C-terminal R186C variant. The other three variants are far less characterized at the functional level....

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Literature Corpus work: 83b4e9f0-e3c8-5b09-9da8-c707ca54dfcd
DOI: 10.1101/2024.06.26.600829

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