Article
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996
Kolluri R, Tolias K F, Carpenter C L, Rosen F S, Kirchhausen T
Abstract excerpt
Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder with the most severe pathology in the T lymphocytes and platelets. The disease arises from mutations in the gene encoding the WAS protein. T lymphocytes of affected males with WAS exhibit a severe disturbance of the actin cytoskeleton, suggesting that the WAS protein could regulate its organization. We show here that WAS protein interacts...
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