Article

Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

2024-12-23

Abstract excerpt

The non-receptor tyrosine phosphatase SHP2 (PTPN11) is a regulator of diverse cellular functions including mitogenic activation and cell migration. SHP2 consists of two tandem SH2 domains followed by the catalytic domain, and is autoinhibited by the N-terminal SH2 domain that blocks access to the active site. Mutations that influence auto-inhibition have been implicated in cancer and other diseases, and allosteric...

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Literature Corpus work: c5cd22e4-8ec6-5f2f-b698-74172cbe85b4
DOI: 10.1101/2024.12.23.630100

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