Article
Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2000
Hengstenberg C, Holmer S R, Mayer B, Löwel H, Engel S, Hense H W, Riegger G A, Schunkert H
Abstract excerpt
Left ventricular remodeling after myocardial infarction involves activation of the renin-angiotensin-aldosterone system. Recently, the biallelic -344T/C polymorphism of the aldosterone synthase gene was associated with increased aldosterone levels, arterial hypertension, diastolic dysfunction, and left ventricular dilatation. We hypothesized that this polymorphism may also affect left ventricular geometry and...
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