Article
Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure.
Circulation - 4 May 1999
Schunkert H, Hengstenberg C, Holmer S R, Broeckel U, Luchner A, Muscholl M W, Kürzinger S, Döring A, Hense H W, Riegger G A
Abstract excerpt
BACKGROUND: Cardiac growth and function may be modulated in part by trophic effects of neurohormones. Specifically, aldosterone has been shown to stimulate the growth of cardiac myocytes and the accumulation of cardiac extracellular matrix proteins. Moreover, a variant of the aldosterone synthase gene (a cytosine/thymidine exchange at position -344 in the transcriptional regulatory region) has been associated...
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