Article
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
Circulation - 30 Nov 1999
Hautanen A, Toivanen P, Mänttäri M, Tenkanen L, Kupari M, Manninen V, Kayes K M, Rosenfeld S, White P C
Abstract excerpt
BACKGROUND: The -344C allele of a 2-allele (C or T) polymorphism in the promoter of the gene encoding aldosterone synthase (CYP11B2) is associated with increased left ventricular size and mass and with decreased baroreflex sensitivity, known risk factors for morbidity and mortality associated with myocardial infarction (MI). We hypothesized that this polymorphism was a risk factor for MI. METHODS AND RESULTS: We...
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