Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.

Abstract excerpt

A common polymorphism exists for the aldosterone synthase (CYP11B2) gene at position 344 (C-344-T). The 344-C allele has been associated with increased aldosterone synthase activity. We hypothesized that the aldosterone synthase gene polymorphism is associated with adverse cardiac remodeling in an ambulatory, chronic heart failure population. The CYP11B2 C-344T genotype was determined in 104 patients with heart...

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