Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma

15 Mar 2000

Abstract excerpt

BACKGROUND: The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma. METHODS: In the current study, Fhit expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic factors in colorectal cancer
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10717620
DOI: 10.1002/(sici)1097-0142(20000315)88:6<1378::aid-cncr15>3.0.co;2-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaPMID 10717620Read ↗

FHIT alterations in breast cancer.Semantic proximity Read ↗

Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.Semantic proximity Read ↗

fhit Alterations in endometrial carcinoma and hyperplasia.Semantic proximity Read ↗

Fhit expression in gastric adenocarcinomaSemantic proximity Read ↗

Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.Semantic proximity Read ↗

Impaired FHIT expression characterizes serous ovarian carcinoma.Semantic proximity Read ↗

Evaluation of the FHIT gene in colorectal cancers.Semantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Fhit is a physiological target of the protein kinase SrcSemantic proximity Read ↗

FHIT gene abnormalities in both benign and malignant thyroid tumours.Semantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.