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Article

Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.

Cancer research - 1 Jun 1999

Ingvarsson S, Agnarsson B A, Sigbjornsdottir B I, Kononen J, Kallioniemi O P, Barkardottir R B, Kovatich A J, Schwarting R, Hauck W W, Huebner K, McCue P A

Abstract excerpt

Evidence for alteration of the FHIT gene in a significant fraction of breast carcinomas has been reported, in apparent concordance with loss of heterozygosity (LOH) at chromosome region 3p14.2 in breast cancer and benign proliferative breast disease. A significantly higher frequency of LOH at the FHIT locus was reported for BRCA2-/- tumors, possibly due to misrepaired double-strand breaks at this common fragile...

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Source

Identifiers

PMID: 10363992

Genes

BRCA2
FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.PMID 10363992Read ↗

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaSemantic proximity Read ↗

FHIT alterations in breast cancer.Semantic proximity Read ↗

Clinicopathologic features and FHIT gene expression in sporadic colorectal adenocarcinomas.Semantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Impaired FHIT expression characterizes serous ovarian carcinoma.Semantic proximity Read ↗

Evaluation of FHIT gene alterations in ovarian cancer.Semantic proximity Read ↗

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.Semantic proximity Read ↗

HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA.Semantic proximity Read ↗

fhit Alterations in endometrial carcinoma and hyperplasia.Semantic proximity Read ↗

FHIT gene abnormalities in both benign and malignant thyroid tumours.Semantic proximity Read ↗

Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

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