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Article

Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25.

The EMBO journal - 15 Mar 2000

Wei S, Xu T, Ashery U, Kollewe A, Matti U, Antonin W, Rettig J, Neher E

Abstract excerpt

The highly conserved SNARE proteins, SNAP-25, syntaxin and synaptobrevin, form a tight ternary complex, which is essential for exocytosis. Crystallization of this complex revealed a four-helix bundle with an unusual hydrophilic layer (zero layer) in its center. In order to evaluate the role of this layer in different kinetic components of secretion, we used the Semliki Forest virus (SFV) system to infect adrenal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10716928
DOI: 10.1093/emboj/19.6.1279
PMCID: PMC305669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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