Article
Fast vesicle fusion in living cells requires at least three SNARE complexes.
Science (New York, N.Y.) - 22 Oct 2010
Mohrmann Ralf, de Wit Heidi, Verhage Matthijs, Neher Erwin, Sørensen Jakob B
Abstract excerpt
Exocytosis requires formation of SNARE [soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complexes between vesicle and target membranes. Recent assessments in reduced model systems have produced divergent estimates of the number of SNARE complexes needed for fusion. Here, we used a titration approach to answer this question in intact, cultured chromaffin cells. Simultaneous expression...
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