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Article

Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells.

The EMBO journal - 15 Jun 1999

Xu T, Ashery U, Burgoyne R D, Neher E

Abstract excerpt

NSF and alpha-SNAP have been shown to be required for SNARE complex disassembly and exocytosis. However, the exact requirement for NSF and alpha-SNAP in vesicular traffic through the secretory pathway remains controversial. We performed a study on the kinetics of exocytosis from bovine chromaffin cells using high time resolution capacitance measurement and electrochemical amperometry, combined with flash...

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Source

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Identifiers

PMID: 10369670
DOI: 10.1093/emboj/18.12.3293
PMCID: PMC1171410

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells.PMID 10369670Read ↗

Molecular analysis of SNAP-25 function in exocytosis.Semantic proximity Read ↗

Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25.Semantic proximity Read ↗

NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cellsSemantic proximity Read ↗

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Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.Semantic proximity Read ↗

Phosphorylation of SNAP-25 at Ser187 mediates enhancement of exocytosis by a phorbol ester in INS-1 cells.Semantic proximity Read ↗

Positively charged amino acids at the SNAP-25 C terminus determine fusion rates, fusion pore properties, and energetics of tight SNARE complex zippering.Semantic proximity Read ↗

The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells.Semantic proximity Read ↗

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Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis.Semantic proximity Read ↗

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