Article
Nerve growth factor alpha subunit: effect of site-directed mutations on catalytic activity and 7S NGF complex formation.
Biochimica et biophysica acta - 7 Mar 2000
Yarski M A, Bax B D, Hogue-Angeletti R A, Bradshaw R A
Abstract excerpt
Mouse alpha- and gamma-nerve growth factor (NGF) are glandular kallikreins that form a non-covalent complex (7S NGF) with beta-NGF. gamma-NGF is an active arginine-specific esteropeptidase; the alpha-subunit is catalytically inactive and has a zymogen-like conformation. Site-directed mutagenesis of alpha-NGF to alter the N-terminus and three residues in loop 7, a region that contributes to the catalytic center,...
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