Article
Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.
The Journal of clinical investigation - 1 Oct 2000
van Rij R P, Blaak H, Visser J A, Brouwer M, Rientsma R, Broersen S, de Roda Husman A M, Schuitemaker H
Abstract excerpt
We demonstrated previously that CD45RA(+) CD4(+) T cells are infected primarily by syncytium-inducing (SI) HIV-1 variants, whereas CD45RO(+) CD4(+) T cells harbor both non-SI (NSI) and SI HIV-1 variants. Here, we studied evolution of tropism for CD45RA(+) and CD45RO(+) CD4(+) cells, coreceptor usage, and molecular phylogeny of coexisting NSI and SI HIV-1 clones that were isolated from four patients in the period...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Evolution, Molecular
- Genetic Variation
- Giant Cells
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Leukocyte Common Antigens
- Male
- Molecular Sequence Data
- Peptide Fragments