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Article

Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.

Journal of virology - 1 Dec 1994

Kaneshima H, Su L, Bonyhadi M L, Connor R I, Ho D D, McCune J M

Abstract excerpt

Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas those obtained afterwards are often characterized as "rapid-high" and syncytium inducing (SI). Paired...

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Source

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Identifiers

PMID: 7966610
DOI: 10.1128/JVI.68.12.8188-8192.1994
PMCID: PMC237284

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Source receipt: pubmed, retrieved 7 Sept 2026.

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