Article
Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.
Journal of virology - 1 Dec 1994
Kaneshima H, Su L, Bonyhadi M L, Connor R I, Ho D D, McCune J M
Abstract excerpt
Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) p...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- CD4 Lymphocyte Count
- Giant Cells
- HIV-1
- Humans
- Lymphocyte Count
- Mice
- Mice, SCID
- Phenotype
- Species Specificity
- T-Lymphocytes
- Thymus Gland
- Time Factors
- Transplantation, Heterologous