Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.

doi:10.1016/j.virol.2004.07.019

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Article

Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope.

Virology - 10 Oct 2004

Meissner Eric G, Duus Karen M, Gao Feng, Yu Xiao-Fang, Su Lishan

Abstract excerpt

Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. One of the isolates (R3A) exhibited markedly rapid kinetics of replication and thymocyte...

Topics

Amino Acid Sequence
Animals
CD4 Antigens
Cell Count
Cells, Cultured
Disease Models, Animal
Disease Progression
Gene Deletion
Gene Products, nef
HIV Infections
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukocytes, Mononuclear

Mice

Mice, SCID

Molecular Sequence Data

Organ Culture Techniques

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 15380360
DOI: 10.1016/j.virol.2004.07.019
PMCID: PMC4429060

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