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Article

Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5.

Journal of virology - 1 Sept 2003

Forte Serene, Harmon Mary-Elizabeth, Pineda Mario J, Overbaugh Julie

Abstract excerpt

Primate lentiviruses are thought to use the chemokine receptor CCR5 as the major coreceptor for entry into cells. Here we show that some variants of simian immunodeficiency virus (SIV) replicate efficiently in peripheral blood mononuclear cells (PBMCs) lacking a functional CCR5. There were differences in the replication patterns of sequential variants that evolved during SIVMne infection; the late-stage...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

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Source

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Identifiers

PMID: 12915585
DOI: 10.1128/jvi.77.17.9723-9727.2003
PMCID: PMC187416

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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