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Article

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

Molecular cell - 7 Jan 2016

Jaenicke Laura A, von Eyss Björn, Carstensen Anne, Wolf Elmar, Xu Wenshan, Greifenberg Ann Katrin, Geyer Matthias, Eilers Martin, Popov Nikita

Abstract excerpt

MYC is an unstable protein, and its turnover is controlled by the ubiquitin system. Ubiquitination enhances MYC-dependent transactivation, but the underlying mechanism remains unresolved. Here we show that MYC proteasomal turnover is dispensable for loading of RNA polymerase II (RNAPII). In contrast, MYC turnover is essential for recruitment of TRRAP, histone acetylation, and binding of BRD4 and P-TEFb to target...

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Topics

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Share to Acetylation
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

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Share to Proteolysis

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 26687678
DOI: 10.1016/j.molcel.2015.11.007

Genes

MYC
TRRAP
BRD4
CDC73
PAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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