Article
Evidence for involvement of calpain in c-Myc proteolysis in vivo.
Archives of biochemistry and biophysics - 15 Apr 2002
Small George W, Chou Teh-Ying, Dang Chi V, Orlowski Robert Z
Abstract excerpt
Precise control of the level of c-Myc protein is important to normal cellular homeostasis, and this is accomplished in part by degradation through the ubiquitin-proteasome pathway. The calpains are a family of calcium-dependent proteases that play important roles in proteolysis of some proteins, and their possible participation in degradation of intracellular c-Myc was therefore investigated. Activation of...
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