Article
Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects.
Atherosclerosis - 1 Mar 2000
Heijmans B T, Westendorp R G, Lagaay A M, Knook D L, Kluft C, Slagboom P E
Abstract excerpt
Recent studies indicate that the enzyme paraoxonase may be an important modulator of cardiovascular disease risk because of its ability to protect LDL from oxidation. We tested for association between two functional variants of the paraoxonase gene (Met-55/Leu and Gln-192/Arg) and both all-cause mortality and fatal cardiovascular disease. This was done within a population-based study among subjects aged 85 years...
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