Article
Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.
Molecular biology reports - 1 Jul 2020
Shahsavari Gholamreza, Nouryazdan Negar, Adibhesami Glavizh, Birjandi Mehdi
Abstract excerpt
The oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays a pivotal role in the initiation and progression of atherosclerosis which is a complex and progressive disorder. Paraoxonase1 (PON1), which is required for lipid metabolism, is believed to protect LDL from oxidation. The relationship between PON1 gene Leusin55Methionin (L55M) and Glutamine192Arginine (Q192R) polymorphisms in...
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