Article
The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1998
Ombres D, Pannitteri G, Montali A, Candeloro A, Seccareccia F, Campagna F, Cantini R, Campa P P, Ricci G, Arca M
Abstract excerpt
Serum paraoxonase (PON) is an HDL-bound enzyme protecting LDL from oxidation. A common polymorphism of the paraoxonase gene (PON1) involving a Gln-to-Arg interchange at position 192 has been demonstrated to modulate PON activity toward paraoxon, a nonphysiological substrate; Arg192 (allele B) is...
Topics
- Adult
- Arginine
- Aryldialkylphosphatase
- Coronary Disease
- Esterases
- Female
- Gene Frequency
- Genotype
- Glutamine
- Humans
- Italy
- Lipids