Article
The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1998
Ombres D, Pannitteri G, Montali A, Candeloro A, Seccareccia F, Campagna F, Cantini R, Campa P P, Ricci G, Arca M
Abstract excerpt
Serum paraoxonase (PON) is an HDL-bound enzyme protecting LDL from oxidation. A common polymorphism of the paraoxonase gene (PON1) involving a Gln-to-Arg interchange at position 192 has been demonstrated to modulate PON activity toward paraoxon, a nonphysiological substrate; Arg192 (allele B) is associated with higher activity than Gln192 (allele A). This polymorphism has been proposed as a genetic marker of risk...
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