Article
Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity: A meta-analysis.
Zeitschrift fur Gerontologie und Geriatrie - 1 Jan 2016
Wei Gan-Zhong, Zhu Mei-Yan, Wang Fang, Zhao Yue-Guang, Li Shan-Shan, Liu Tong-Yang, Luo Ying, Tang Wen-Ru
Abstract excerpt
BACKGROUND: Genetic mutations in the paraoxonase 1 (PON1) encoding gene have been considered to affect mortality and of these the functional promoter region polymorphisms Q192R and L55M are among the most widely studied. OBJECTIVE: The aim of this study was to determine whether the Q192R and L55M polymorphisms of PON1 can increase susceptibility to longevity. A meta-analysis was performed to obtain a...
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