Article
Mutations in the human paraoxonase 1 gene: frequencies, allelic linkages, and association with coronary artery disease.
Pharmacogenetics - 1 Dec 1999
Cascorbi I, Laule M, Mrozikiewicz P M, Mrozikiewicz A, Andel C, Baumann G, Roots I, Stangl K
Abstract excerpt
Oxidative damage is a major cause of atherosclerosis. Since human paraoxonase has been postulated as a factor which plays a role in protection from low density lipoprotein oxidation, recent studies have dealt with the impact of hereditary PON1 gene polymorphisms as risk factors for coronary artery disease (CAD). The results from these studies are conflicting. In a case-control study, 1000 Caucasian patients with...
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