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Article

Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces.

Acta biomaterialia - 1 Jan 2020

Bijukumar Divya Rani, Salunkhe Shruti, Zheng Guoxing, Barba Mark, Hall Deborah J, Pourzal Robin, Mathew Mathew T

Abstract excerpt

Evidence that macrophages can play a role in accelerating corrosion in CoCrMo alloy in total hip replacement (THR) interfaces leads to questions regarding the underlying cellular mechanisms and immunological responses. Hence, we evaluated the role of macrophages in corrosion processes using the cell culture supernatant from different conditions and the effect of wear particles on macrophage dynamics. Monocytes...

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Identifiers

PMID: 31678260
DOI: 10.1016/j.actbio.2019.10.039
PMCID: PMC7370988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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