Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide.

Psychiatry research - 14 Feb 2000

Russ M J, Lachman H M, Kashdan T, Saito T, Bajmakovic-Kacila S

Abstract excerpt

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Membrane Transport Proteins

Share to Mental Disorders

Share to Psychiatric Status Rating Scales

Share to Serotonin

Share to Serotonin Plasma Membrane Transport Proteins

Source

Identifiers

PMID: 10699230
DOI: 10.1016/s0165-1781(00)00128-1

Genes

HTT
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide.PMID 10699230Read ↗

Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.Semantic proximity Read ↗

No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains.Semantic proximity Read ↗

The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.Semantic proximity Read ↗

Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity.Semantic proximity Read ↗

Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.Semantic proximity Read ↗

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior.Semantic proximity Read ↗

The serotonin transporter promoter polymorphism and suicide.Semantic proximity Read ↗

Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan.Semantic proximity Read ↗

A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.