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Article

A Dynamic View of the Interaction of Histone Tails with Clustered Abasic Sites in a Nucleosome Core Particle.

The journal of physical chemistry letters - 1 Jul 2021

Bignon Emmanuelle, Gillet Natacha, Jiang Tao, Morell Christophe, Dumont Elise

Abstract excerpt

Apurinic/apyrimidinic sites are the most common forms of DNA damage under physiological conditions, yet their structural and dynamical behavior within nucleosome core particles has just begun to be investigated and is dramatically different from that of abasic sites in B-DNA. Clusters of two or more abasic sites are repaired even less efficiently and hence constitute hot spots of high mutagenicity notably due to...

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PMID: 34165307
DOI: 10.1021/acs.jpclett.1c01058

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