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Article

Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.

Clinical and experimental immunology - 1 Mar 2000

Tse W Y, Abadeh S, Jefferis R, Savage C O, Adu D

Abstract excerpt

Neutrophils constitutively express FcgammaRIIa and FcgammaRIIIb receptors. Both receptors exhibit allelic variants which have different quantitative functional capacities: the biallelic FcgammaRIIa-R131 and -H131 alleles, and the neutrophil antigen (NA) NA1/NA2 alleles. ANCA activation of neutrophils requires ligation of FcgammaRIIa receptor, but recent data have shown that ANCA can also bind FcgammaRIIIb...

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Share to Alleles
Share to Antibodies, Antineutrophil Cytoplasmic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MPO gene

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Share to Polymorphism, Genetic

Share to Receptors, IgG

Share to Vasculitis

Source

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Identifiers

PMID: 10691933
DOI: 10.1046/j.1365-2249.2000.01182.x
PMCID: PMC1905578

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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