IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.

doi:10.1073/pnas.1109227109

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Article

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011

Kelley James M, Monach Paul A, Ji Chuanyi, Zhou Yebin, Wu Jianming, Tanaka Sumiaki, Mahr Alfred D, Johnson Sharleen, McAlear Carol, Cuthbertson David, Carette Simon, Davis John C, Dellaripa Paul F, Hoffman Gary S, Khalidi Nader, Langford Carol A, Seo Phillip, St Clair E William, Specks Ulrich, Stone John H, Spiera Robert F, Ytterberg Steven R, Merkel Peter A, Edberg Jeffrey C, Kimberly Robert P

Abstract excerpt

Granulomatosis with polyangiitis (Wegener's) is a rare autoimmune neutrophil-mediated vasculitis that can cause renal disease and mucosal manifestations. Antineutrophil cytoplasmic antibodies (ANCA) are present in many patients, vary in level over time, and induce neutrophil activation through engagement with Fc receptors (FcRs). Given roles for FcRs in ANCA-mediated neutrophil activation and IgA antibodies in...

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PMID: 22147912
DOI: 10.1073/pnas.1109227109
PMCID: PMC3251158

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FCAR

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