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Article

Genetic variations in low-to-medium-affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort.

International journal of immunogenetics - 1 Apr 2023

Kløve-Mogensen Kirstine, Steffensen Rudi, Masmas Tania Nicole, Glenthøj Andreas, Jensen Christina Friis, Haunstrup Thure Mors, Ratcliffe Paul, Höglund Petter, Hasle Henrik, Nielsen Kaspar René

Abstract excerpt

Autoimmune neutropenia (AIN) in early childhood is caused by autoantibodies directed against antigens on the neutrophil membrane and is a frequent cause of neutropenia in children. Association of AIN with Fcγ receptor (FCGR) 3B variants is well described. In this study, we investigate genetic variations in the FCGR locus and copy number variation of FCGR3B. A total of 130 antibody-positive AIN patients, 64 with...

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PMID: 36754570
DOI: 10.1111/iji.12614

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