Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HLA-E locus is associated with age at onset and susceptibility to type 1 diabetes mellitus.

Human immunology - 1 Mar 2000

Hodgkinson A D, Millward B A, Demaine A G

Abstract excerpt

Previous studies have suggested that the human leukocyte antigen (HLA) class I region may be involved in determining the age at onset and clinical severity of type 1 diabetes. We have investigated the frequency of polymorphisms of the nonclassical HLA class I gene, HLA-E, in 199 British Caucasian patients with type 1 diabetes and 82 healthy controls. A highly significant increase in the frequency of the HLA-E...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Child, Preschool
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA Antigens

Share to HLA-E Antigens

Share to United Kingdom

Share to White People

Source

Identifiers

PMID: 10689118
DOI: 10.1016/s0198-8859(99)00116-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HLA-E locus is associated with age at onset and susceptibility to type 1 diabetes mellitus.PMID 10689118Read ↗

Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset.Semantic proximity Read ↗

HLA-G 14-bp polymorphism affects the age of onset in Type I Diabetes Mellitus.Semantic proximity Read ↗

Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations.Semantic proximity Read ↗

A new marker in the HLA class I region is associated with the age at onset of IDDM.Semantic proximity Read ↗

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Distribution of HLA class I alleles differs in celiac disease patients according to age of onset.Semantic proximity Read ↗

Age-related association of MHC class I chain-related gene A (MICA) with type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Early age of disease onset in African American type 1 diabetes patients is associated with DQB1*0201 allele.Semantic proximity Read ↗

Association between type 1 diabetes age of onset and HLA among sibling pairs.Semantic proximity Read ↗

HLA-DQ genotype in early onset insulin dependent diabetes mellitus.Semantic proximity Read ↗

Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism.Semantic proximity Read ↗

Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.