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Article

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

The Journal of clinical investigation - 1 Dec 1992

Caillat-Zucman S, Garchon H J, Timsit J, Assan R, Boitard C, Djilali-Saiah I, Bougnères P, Bach J F

Abstract excerpt

The association of insulin-dependent diabetes mellitus (IDDM) with certain HLA alleles is well documented in pediatric patients. Whether a similar association is found in adult-on-set IDDM is not clear, although the disease occurs after the age of 20 in 50% of cases. HLA class II DRB1, DQA1, and DQB1 alleles were studied in 402 type I diabetics and 405 healthy controls (all Caucasian) using oligonucleotide typing...

Topics

Adolescent
Adult
Age Factors
Alleles
Diabetes Mellitus, Type 1
Genes, MHC Class II
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
Humans
Risk Factors

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Identifiers

PMID: 1469084
DOI: 10.1172/JCI116110
PMCID: PMC443375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1469084-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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