Article
Association between type 1 diabetes age of onset and HLA among sibling pairs.
Diabetes - 1 Aug 1999
Valdes A M, Thomson G, Erlich H A, Noble J A
Abstract excerpt
In this study, we report type 1 diabetes age-of-onset association with HLA class II (DRB1, DQB1, and DPB1) and class I (A) genes in 222 multiplex families from the Human Biological Data Interchange. Linear regression showed a small (R2 = 0.26) but significant correlation in the ages of onset among sib pairs. A strong association in age of onset between members of sib pairs was observed when the analysis was...
Topics
- Adolescent
- Adult
- Age of Onset
- Alleles
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- HLA Antigens
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Infant
- Infant, Newborn